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Mistletoe is the general term given to the parasitic and hemi-parasitic tree dwelling genuses of the family Viscaceae which contains three genera of mistletoe:

Mistletoe is the general term given to the parasitic and hemi-parasitic tree dwelling genuses of the family Viscaceae which contains three genera of mistletoe:

#Arceuthobium (dwarf mistletoe)

#[[Wikipedia:Arceuthobium|Arceuthobium]] (Dwarf mistletoe)

#Phoradendron (American mistletoe)

#[[Wikipedia:Phoradendron|Phoradendron]] (American mistletoe)

#Viscum (mistletoe)<ref>{{cite book | vauthors=((Agrios, G. N.)) | date= 2005 | chapter=Plant Pathology | title=PLANT DISEASES CAUSED BY PARASITIC HIGHER PLANTS, INVASIVE CLIMBING PLANTS, AND PARASITIC GREEN ALGAE | publisher=Elsevier | pages=705–722 | url=https://linkinghub.elsevier.com/retrieve/pii/B9780080473789500191 | doi=10.1016/B978-0-08-047378-9.50019-1 | isbn=9780120445653}}</ref>

#[[Wikipedia:Viscum|Viscum]] (Mistletoe)<ref>{{cite book | vauthors=((Agrios, G. N.)) | date= 2005 | chapter=Plant Pathology | title=PLANT DISEASES CAUSED BY PARASITIC HIGHER PLANTS, INVASIVE CLIMBING PLANTS, AND PARASITIC GREEN ALGAE | publisher=Elsevier | pages=705–722 | url=https://linkinghub.elsevier.com/retrieve/pii/B9780080473789500191 | doi=10.1016/B978-0-08-047378-9.50019-1 | isbn=9780120445653}}</ref>

[[American Mistletoe]] ([[Phoradendron]] serotinum) has a history of use in Mexican and South American traditional medicine for the treatment of cancer.<ref>{{cite journal | vauthors=((Alonso-Castro, A. J.)), ((Juárez-Vázquez, M. del C.)), ((Domínguez, F.)), ((González-Sánchez, I.)), ((Estrada-Castillón, E.)), ((López-Toledo, G.)), ((Chávez, M.)), ((Cerbón, M. A.)), ((García-Carranca, A.)) | journal=Journal of Ethnopharmacology | title=The antitumoral effect of the American mistletoe Phoradendron serotinum (Raf.) M.C. Johnst. (Viscaceae) is associated with the release of immunity-related cytokines | volume=142 | issue=3 | pages=857–864 | date=1 August 2012 | url=https://www.sciencedirect.com/science/article/pii/S0378874112004175 | doi=10.1016/j.jep.2012.06.018 | access-date=13 March 2023}}</ref>

[[American Mistletoe]] ([[Wikipedia:Phoradendron serotinum|Phoradendron serotinum]]) has a history of use in Mexican and South American traditional medicine for the treatment of cancer.<ref>{{cite journal | vauthors=((Alonso-Castro, A. J.)), ((Juárez-Vázquez, M. del C.)), ((Domínguez, F.)), ((González-Sánchez, I.)), ((Estrada-Castillón, E.)), ((López-Toledo, G.)), ((Chávez, M.)), ((Cerbón, M. A.)), ((García-Carranca, A.)) | journal=Journal of Ethnopharmacology | title=The antitumoral effect of the American mistletoe Phoradendron serotinum (Raf.) M.C. Johnst. (Viscaceae) is associated with the release of immunity-related cytokines | volume=142 | issue=3 | pages=857–864 | date=1 August 2012 | url=https://www.sciencedirect.com/science/article/pii/S0378874112004175 | doi=10.1016/j.jep.2012.06.018 | access-date=13 March 2023}}</ref>

==History of Clinical Use==

==History of Clinical Use==

*A 2014 study found that intratumoral injection of mistletoe gave an anticipated amount of local inflammation around the tumor as well as fever. These side effects were generally tolerable and intratumoral mistletoe was found to be safe and the side effects part of the anticancer working of mistletoe. "Intratumoral injection of mistletoe preparations resulted in a relatively high frequency of adverse drug reactions. Nearly all adverse drug reactions were mild to moderate however, and no serious adverse drug reactions occurred. Furthermore, it is possible that immune-related adverse drug reactions such as pyrexia and local inflammatory reactions might be critical for tumor response."<ref>{{cite journal | vauthors=((Steele, M. L.)), ((Axtner, J.)), ((Happe, A.)), ((Kröz, M.)), ((Matthes, H.)), ((Schad, F.)) | journal=Integrative Cancer Therapies | title=Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology | volume=14 | issue=2 | pages=140–148 | date=1 March 2015 | url=https://doi.org/10.1177/1534735414563977 | doi=10.1177/1534735414563977 | access-date=15 January 2023}}</ref>

*A 2014 study found that intratumoral injection of mistletoe gave an anticipated amount of local inflammation around the tumor as well as fever. These side effects were generally tolerable and intratumoral mistletoe was found to be safe and the side effects part of the anticancer working of mistletoe. "Intratumoral injection of mistletoe preparations resulted in a relatively high frequency of adverse drug reactions. Nearly all adverse drug reactions were mild to moderate however, and no serious adverse drug reactions occurred. Furthermore, it is possible that immune-related adverse drug reactions such as pyrexia and local inflammatory reactions might be critical for tumor response."<ref>{{cite journal | vauthors=((Steele, M. L.)), ((Axtner, J.)), ((Happe, A.)), ((Kröz, M.)), ((Matthes, H.)), ((Schad, F.)) | journal=Integrative Cancer Therapies | title=Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology | volume=14 | issue=2 | pages=140–148 | date=1 March 2015 | url=https://doi.org/10.1177/1534735414563977 | doi=10.1177/1534735414563977 | access-date=15 January 2023}}</ref>

=== Meta-analysis ===

===Meta-analysis===

=== Specific Cancer Types ===

===Specific Cancer Types===

==== Breast Cancer ====

====Breast Cancer====

==== Colorectal Cancer ====

====Colorectal Cancer====

==== Non Small Cell Lung Cancer ====

====Non Small Cell Lung Cancer====

==== Pancreatic Cancer ====

====Pancreatic Cancer====

=== General Findings ===

===General Findings===

==== Effects on the Immune System ====

====Effects on the Immune System====

==== Increased Vitality ====

====Increased Vitality====

==== Quality of Life ====

====Quality of Life====

==== Decreased Side Effects from Chemotherapy ====

====Decreased Side Effects from Chemotherapy====

=== Current Clinical Trials ===

===Current Clinical Trials===

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==Current Clinical Use==

==Current Clinical Use==