*A 2008 systematic literature review<ref name=":1" /> found a small number of studies (1 prospective clinical study, 3 experimental studies with healthy subjects, 5 case reports, and 3 experience reports). The studies described improvement in almost all cases, although the methodological quality of most studies was weak. The main indications were metabolic/internal, and psychiatric/neurologic. | *A 2008 systematic literature review<ref name=":1" /> found a small number of studies (1 prospective clinical study, 3 experimental studies with healthy subjects, 5 case reports, and 3 experience reports). The studies described improvement in almost all cases, although the methodological quality of most studies was weak. The main indications were metabolic/internal, and psychiatric/neurologic. |