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{{Infobox Study|publications={{cite journal | vauthors=((Büssing, A.)), ((Raak, C.)), ((Ostermann, T.)) | journal=Evidence-based Complementary and Alternative Medicine : eCAM | title=Quality of Life and Related Dimensions in Cancer Patients Treated with Mistletoe Extract (Iscador): A Meta-Analysis | volume=2012 | pages=219402 | date= 2012 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124023/ | doi=10.1155/2012/219402 | access-date=16 March 2023}}|study type=Meta-analysis}}
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Büssing et al examined 734 patients treated with subcutaneous Iscador versus 741 controls in 13 controlled trials (9 of which were randomized) and looked at differences in quality of life.<ref>{{cite journal | vauthors=((Büssing, A.)), ((Raak, C.)), ((Ostermann, T.)) | journal=Evidence-based Complementary and Alternative Medicine : eCAM | title=Quality of Life and Related Dimensions in Cancer Patients Treated with Mistletoe Extract (Iscador): A Meta-Analysis | volume=2012 | pages=219402 | date= 2012 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124023/ | doi=10.1155/2012/219402 | access-date=16 March 2023}}</ref> Though the included studies suffered from
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quality issues such as lacking description of intention to treat analysis, compliance, and enrolled less than 200 patients, most trials were randomized and all of the results pointed to significant quality of life effects, despite high heterogeneity.{{Infobox Study|publications={{cite journal | vauthors=((Büssing, A.)), ((Raak, C.)), ((Ostermann, T.)) | journal=Evidence-based Complementary and Alternative Medicine : eCAM | title=Quality of Life and Related Dimensions in Cancer Patients Treated with Mistletoe Extract (Iscador): A Meta-Analysis | volume=2012 | pages=219402 | date= 2012 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124023/ | doi=10.1155/2012/219402 | access-date=16 March 2023}}|study type=Meta-analysis}}
    
==Abstract==
 
==Abstract==
''Objectives''. The aim of this meta-analysis was to determine the effectiveness of the fermented plant extract ''Iscador'', produced from the white-berry European mistletoe, in the treatment of patients with cancer with respect to quality-of-life- (QoL-) associated measures. ''Methods''. We searched databases such as PubMed/Medline, Excerpta Medica Database (EMBASE), CAMbase, and other for controlled clinical studies on parameters associated with QoL. Outcome data were extracted and converted into standardized mean differences and their standard errors. ''Results''. Thirteen prospective and controlled studies which met the inclusion/exclusion criteria reported positive effects in favor of the ''Iscador'' application. A random-effect meta-analysis estimated the overall treatment effect at standardized mean difference = 0.56 (CI: 0.41 to 0.71, ''P'' < .0001). However, the methodological quality of the studies was poor. ''Conclusions''. The analyzed studies give some evidence that ''Iscador'' treatment might have beneficial short-time effects on QoL-associated dimensions and psychosomatic self-regulation.
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''Objectives''. The aim of this meta-analysis was to determine the effectiveness of the fermented plant extract ''Iscador'', produced from the white-berry European mistletoe, in the treatment of patients with cancer with respect to quality-of-life- (QoL-) associated measures. ''Methods''. We searched databases such as PubMed/Medline, Excerpta Medica Database (EMBASE), CAMbase, and other for controlled clinical studies on parameters associated with QoL. Outcome data were extracted and converted into standardized mean differences and their standard errors. ''Results''. Thirteen prospective and controlled studies which met the inclusion/exclusion criteria reported positive effects in favor of the ''Iscador'' application. A random-effect meta-analysis estimated the overall treatment effect at standardized mean difference = 0.56 (CI: 0.41 to 0.71, ''P'' < .0001). However, the methodological quality of the studies was poor. ''Conclusions''. The analyzed studies give some evidence that ''Iscador'' treatment might have beneficial short-time effects on QoL-associated dimensions and psychosomatic self-regulation. <gallery widths="500" heights="500" perrow="2">
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File:Bussing et al 2012 meta analysis.jpg|Meta analysis standard mean difference effects showing an overall treatment effect at SMD = 0.56 (CI: 0.41 to 0.71, ''P'' < .0001), indicating a moderate effect.
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File:Bussing plausible cause of QOL.jpg| Hypothetical diagram explaining the possible mechanisms of ''Viscum album'' extract application on QoL. Büssing, A., Raak, C., & Ostermann, T. (2012). Quality of Life and Related Dimensions in Cancer Patients Treated with Mistletoe Extract (Iscador): A Meta-Analysis. ''Evidence-Based Complementary and Alternative Medicine : ECAM'', ''2012'', 219402. https://doi.org/10.1155/2012/21940 
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</gallery>
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== References ==
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<references />
 
[[Category:Mistletoe]]
 
[[Category:Mistletoe]]
 
[[Category:Mistletoe therapy]]
 
[[Category:Mistletoe therapy]]
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