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[[R. Adam Engle|Engle]], [[Francisco Varela|Varela]], and the [[Wikipedia:14th Dalai Lama|Dalai Lama]] saw Buddhism and science as different methodologies with a similar aim: to investigate nature and reality, using knowledge gained to improve the quality of life and the planet.<ref name="BGK">{{cite web|author1=Vincent Horn|title=The Evolution of the Mind and Life Dialogues|url=http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|publisher=Buddhist Geeks|access-date=9 May 2015|ref=BD 122|quote=And Buddhism ... is based on also understanding the nature of reality and then using that to provide a knowledge base for improving lives|url-status=dead|archive-url=https://web.archive.org/web/20150504061533/http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|archive-date=4 May 2015}}</ref> They concurred that science uses technology and the scientific method as its means while Buddhism uses the human nervous system refined by meditation and rigorous mental and emotional training.<ref name="GB" /><ref name="MITTR">{{cite web|author1=Curt Newton|title=Meditation and the Brain|url=http://www.technologyreview.com/news/402450/meditation-and-the-brain/|website=technologyreview.com|publisher=MIT Technology Review|date=February 1, 2004|quote=The Dalai Lama notes that both traditions encourage challenging dogma based on observation and analysis, and a willingness to revise views based on empirical evidence.}}</ref> Until then, there had been no mechanism for scientists and Buddhist masters to meet and share their findings in dialogue. The concept pioneered a new interdisciplinary, cross-cultural engagement.<ref name="Plasticmind" /><ref>Watson 2008, [https://books.google.com/books?id=80JNDfdTA2MC&lpg=PP1&pg=PA169&redir_esc=y#v=onepage&q&f=false p.169]</ref>

[[R. Adam Engle|Engle]], [[Francisco Varela|Varela]], and the [[Wikipedia:14th Dalai Lama|Dalai Lama]] saw Buddhism and science as different methodologies with a similar aim: to investigate nature and reality, using knowledge gained to improve the quality of life and the planet.<ref name="BGK">{{cite web|author1=Vincent Horn|title=The Evolution of the Mind and Life Dialogues|url=http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|publisher=Buddhist Geeks|access-date=9 May 2015|ref=BD 122|quote=And Buddhism ... is based on also understanding the nature of reality and then using that to provide a knowledge base for improving lives|url-status=dead|archive-url=https://web.archive.org/web/20150504061533/http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|archive-date=4 May 2015}}</ref> They concurred that science uses technology and the scientific method as its means while Buddhism uses the human nervous system refined by meditation and rigorous mental and emotional training.<ref name="GB" /><ref name="MITTR">{{cite web|author1=Curt Newton|title=Meditation and the Brain|url=http://www.technologyreview.com/news/402450/meditation-and-the-brain/|website=technologyreview.com|publisher=MIT Technology Review|date=February 1, 2004|quote=The Dalai Lama notes that both traditions encourage challenging dogma based on observation and analysis, and a willingness to revise views based on empirical evidence.}}</ref> Until then, there had been no mechanism for scientists and Buddhist masters to meet and share their findings in dialogue. The concept pioneered a new interdisciplinary, cross-cultural engagement.<ref name="Plasticmind" /><ref>Watson 2008, [https://books.google.com/books?id=80JNDfdTA2MC&lpg=PP1&pg=PA169&redir_esc=y#v=onepage&q&f=false p.169]</ref>

[[R. Adam Engle|Engle]] organized the original Mind and Life Dialogue in October 1987 at the Dalai Lama’s residence in [[Wikipedia:Dharamshala|Dharamshala]], India as  a week-long event.<ref>Hayward, Varela 1992, Preface</ref> Six scientists including Varela, two interpreters and the Dalai Lama spent five hours daily, sharing views and discussing the sciences of the mind.<ref name="Plasticmind" /> At the end, Engle asked the Dalai Lama if he wanted to do it again. The answer was "yes," and the series of dialogues was born.<ref name="BG122">{{cite web|author1=Vincent Horn|title=The Evolution of the Mind and Life Dialogues|url=http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|publisher=Buddhist Geeks|access-date=9 May 2015|ref=BD 122|url-status=dead|archive-url=https://web.archive.org/web/20150504061533/http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|archive-date=4 May 2015}}</ref>

[[R. Adam Engle|Engle]] organized the original Mind and Life Dialogue in October 1987 at the Dalai Lama’s residence in [[Wikipedia:Dharamshala|Dharamshala]], India as  a week-long event.<ref>Hayward, Varela 1992, Preface</ref> Six scientists including Varela and two interpreters gathered with His Holiness and spent five hours daily, sharing views and discussing the sciences of the mind<ref name="Plasticmind" /> in what was described as a ‘living room conversation.’. They explored topics ranging from cognitive psychology, perception, memory, and the development of the brain to causality and karma.<ref>{{Cite web| language = en-US| last = Engle| first = Adam| title = Planting Seeds for a New Research Field: Lessons from the Early Days of Mind & Life| work = Mind & Life Institute| accessdate = 2022-02-22| date = 2022-02-13| url = https://www.mindandlife.org/insight/planting-seeds-for-a-new-research-field-lessons-from-the-early-days-of-mind-life/}}</ref> At the end, Engle asked the Dalai Lama if he wanted to do it again. The answer was "yes," and the series of dialogues was born.<ref name="BG122">{{cite web|author1=Vincent Horn|title=The Evolution of the Mind and Life Dialogues|url=http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|publisher=Buddhist Geeks|access-date=9 May 2015|ref=BD 122|url-status=dead|archive-url=https://web.archive.org/web/20150504061533/http://www.buddhistgeeks.com/2009/05/bg-122-the-evolution-of-the-mind-and-life-dialogues/|archive-date=4 May 2015}}</ref>

The second dialogue was a two-day event in October 1989 in [[Wikipedia:Newport Beach, California|Newport Beach]], California.<ref name="Plasticmind" /> At the third dialogue, held in Dharamsala in 1990, it was decided that in order to organize and fund further dialogues and potential research programmes  the Mind and Life Institute should be incorporated as a non-profit organization in the USA.<ref>Begley 2007, p.258</ref><ref>{{cite web|title=Speakers and Panelists for Investigating the Mind 2005|url=http://www.investigatingthemind.org/speakers.html|publisher=The Mind and Life Institute|access-date=9 May 2015|date=2003|quote=[Adam Engle] co-founded the Mind and Life dialogues in 1983, and formed the Mind and Life Institute in 1990|url-status=dead|archive-url=https://web.archive.org/web/20150220033300/http://investigatingthemind.org/speakers.html|archive-date=20 February 2015}}</ref><ref>Watson 2008, [https://books.google.com/books?id=80JNDfdTA2MC&lpg=PP1&pg=PA169&redir_esc=y#v=onepage&q&f=false p.170]</ref> The institute was incorporated in 1991. Engle was elected Chair and CEO, a post he held for 22 years until his retirement in 2012 having guided its development into "a worldwide and influential  organization bringing together the highest standards of modern science and contemplative practice." Engle was then succeeded by the physicist and author [[Arthur Zajonc]].<ref>{{cite web|author1=Matthieu Ricard|title=Celebrating the Twenty-Fifth Anniversary of the Mind and Life Institute|url=http://www.matthieuricard.org/en/blog/posts/celebrating-the-twenty-fifth-anniversary-of-the-mind-and-life-institute|website=Matthieu Ricard, Buddhist monk, photographer and author|access-date=28 July 2015|date=January 18, 2013}}</ref>

The second dialogue was a two-day event in October 1989 in [[Wikipedia:Newport Beach, California|Newport Beach]], California.<ref name="Plasticmind" /> At the third dialogue, held in Dharamsala in 1990, it was decided that in order to organize and fund further dialogues and potential research programmes  the Mind and Life Institute should be incorporated as a non-profit organization in the USA.<ref>Begley 2007, p.258</ref><ref>{{cite web|title=Speakers and Panelists for Investigating the Mind 2005|url=http://www.investigatingthemind.org/speakers.html|publisher=The Mind and Life Institute|access-date=9 May 2015|date=2003|quote=[Adam Engle] co-founded the Mind and Life dialogues in 1983, and formed the Mind and Life Institute in 1990|url-status=dead|archive-url=https://web.archive.org/web/20150220033300/http://investigatingthemind.org/speakers.html|archive-date=20 February 2015}}</ref><ref>Watson 2008, [https://books.google.com/books?id=80JNDfdTA2MC&lpg=PP1&pg=PA169&redir_esc=y#v=onepage&q&f=false p.170]</ref> The institute was incorporated in 1991. Engle was elected Chair and CEO, a post he held for 22 years until his retirement in 2012 having guided its development into "a worldwide and influential  organization bringing together the highest standards of modern science and contemplative practice." Engle was then succeeded by the physicist and author [[Arthur Zajonc]].<ref>{{cite web|author1=Matthieu Ricard|title=Celebrating the Twenty-Fifth Anniversary of the Mind and Life Institute|url=http://www.matthieuricard.org/en/blog/posts/celebrating-the-twenty-fifth-anniversary-of-the-mind-and-life-institute|website=Matthieu Ricard, Buddhist monk, photographer and author|access-date=28 July 2015|date=January 18, 2013}}</ref>