Repurposed Medications

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Repurposed medicines are medications that are used off label to address a concern. The use of medicines in a repurposed manner encompasses both conventional (broadly accepted) medical practice as well as unconventional medicine. An example of a widely accepted repurposed medicine is misoprostol. This medicine is approved by the FDA for prevention of gastric ulcers[1] but is almost entirely used in obstetrics for induction of labor and to treat postpartum hemorrhage. The REDO Project is a less conventionally accepted approach involving repurposing drugs in oncology. Usual drug candidates are old, inexpensive and with a known safety profile. Much of research is driven in the pharmaceutical world by profit so these inexpensive and off-patent medications might otherwise be left unresearched if not for the efforts of this nonprofit group[2]. Metformin is an example of one oncology drug candidate that has recently been the subject of more research in oncology with multiple clinical trials ongoing[3]. Jane Mclelland authored a book describing her use of multiple repurposed drugs and supplements in blocking cancer's metabolic pathways. In her case she maintains long remission from stage 4 cervical cancer[4]. The Care Oncology Clinic uses a repurposed drug regimen to augment treatment in cancer patients and these medications and more are used by many other providers as an off label use[5].