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| ==Botany== | | ==Botany== |
− | Mistletoe is the general term given to the parasitic and hemi-parasitic tree dwelling genuses of the family [[Wikipedia:Viscaceae|Viscaceae]] which contains three genera of mistletoe: | + | Mistletoe is the general term given to the parasitic and hemi-parasitic tree dwelling members of the family [[Wikipedia:Viscaceae|Viscaceae]] which contains three genera of mistletoe: |
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| #[[Wikipedia:Arceuthobium|Arceuthobium]] (Dwarf mistletoe) | | #[[Wikipedia:Arceuthobium|Arceuthobium]] (Dwarf mistletoe) |
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| ==Scientific Evidence== | | ==Scientific Evidence== |
− | [[File:Pubmed mistletoe.png|none|thumb|450x450px|Cumulative PubMed articles by year with the terms "Mistletoe" and "Cancer"]] | + | [[File:Pubmed image2.png|alt=|none|thumb|450x450px|Cumulative PubMed articles by year with the terms "Mistletoe" and "Cancer"]] |
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| ===Safety Trials=== | | ===Safety Trials=== |
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| ===Current Clinical Trials=== | | ===Current Clinical Trials=== |
− | <br /> | + | As of March 2023 a phase 3 randomized trial is recruiting for patients with superficial bladder cancer. One arm will receive instillations of abnoba mistletoe into their bladder and compared with the chemotherapy mitomycin c.<ref>https://clinicaltrials.gov/ct2/show/NCT02106572</ref> |
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| + | A phase 2, single arm study of osteosarcoma patients with fully resected pulmonary metastases will be conducted at [[:en:MD_Anderson_Cancer_Center|University of Texas MD Anderson Cancer Center]]. Participants will receive Iscador® Pini as a prophylactic immunotherapy.<ref>https://beta.clinicaltrials.gov/study/NCT05726383</ref> This trial replicates in part the 2007 two armed study of post relapse disease free survival in fully resected osteosarcoma. One arm receiving etoposide had an average survival of 7 months (all had recurrence) and the other receiving Iscador Pini had a median survival of 106 months (5 out of 9 without recurrence). <ref><nowiki><ref>{{cite journal | vauthors=((Longhi, A.)), ((Cesari, M.)), ((Serra, M.)), ((Mariani, E.)) | journal=Sarcoma | title=Long-Term Follow-up of a Randomized Study of Oral Etoposide versus </nowiki>''Viscum album'' Fermentatum Pini as Maintenance Therapy in Osteosarcoma Patients in Complete Surgical Remission after Second Relapse | volume=2020 | pages=e8260730 | date=27 April 2020 | url=<nowiki>https://www.hindawi.com/journals/sarcoma/2020/8260730/</nowiki> | doi=10.1155/2020/8260730 | access-date=15 March 2023}}<nowiki></ref></nowiki></ref> |
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| + | A Phase 1, dose finding trial is being conducted on Iscador Pini in Israel. <ref>https://beta.clinicaltrials.gov/study/NCT04376931</ref><br /> |
| ==Current Clinical Use== | | ==Current Clinical Use== |
| A main field of use in [[anthroposophic medicine]] is the treatment of [[cancer]], there is also nononcological uses for example in [[Wikipedia:Rheumatic disorders|rheumatic disorders]]. | | A main field of use in [[anthroposophic medicine]] is the treatment of [[cancer]], there is also nononcological uses for example in [[Wikipedia:Rheumatic disorders|rheumatic disorders]]. |